EX-10.2

Exhibit 10.2

SIXTH SUPPLEMENTAL INDENTURE

Dated as of September 9, 2026

Supplementing that Certain

INDENTURE

Dated as of September 2, 2020

Among

ROYALTY PHARMA PLC,

ROYALTY PHARMA HOLDINGS LTD.

ROYALTY PHARMA MANAGER, LLC

and

WILMINGTON TRUST, NATIONAL ASSOCIATION, as Trustee

This Sixth Supplemental Indenture, dated as of September 9, 2026 (this “Sixth Supplemental

Indenture”), among Royalty Pharma plc, an English public limited company incorporated under the laws of

England and Wales, having its principal office at 110 East 59th Street, New York, NY 10022 (the

“Company”), Royalty Pharma Holdings Ltd. (the “Initial Guarantor”), Royalty Pharma Manager, LLC (the

“Additional Guarantor” and, together with the Initial Guarantor, the “Guarantors”), and Wilmington Trust,

National Association, as Trustee under the Indenture (as hereinafter defined) and hereunder (the “Trustee”),

supplements and amends that certain Indenture, dated as of September 2, 2020, among the Company, the

Guarantors and the Trustee (as supplemented and amended by the First Supplemental Indenture, dated as of

September 2, 2020, the Second Supplemental Indenture, dated as of July 26, 2021, the Third Supplemental

Indenture, dated as of June 10, 2024, the Fourth Supplemental Indenture, dated as of June 9, 2025 and the

Fifth Supplemental Indenture, dated as of September 16, 2025, the “Base Indenture” and, together with this

Sixth Supplemental Indenture, the “Indenture”). Capitalized terms used but not defined in this Sixth

Supplemental Indenture shall have the meanings ascribed to them in the Base Indenture.

WHEREAS, Section 1410(3) of the Base Indenture provides that a Guarantor other than the Initial

Guarantor is automatically and unconditionally released and discharged from all obligations under the

Indenture and its Guarantee without any action required on the part of the Trustee or any Holder upon the

request of the Company and the receipt by the Trustee of an Officers’ Certificate certifying that such

Guarantor is not a guarantor or obligor in respect of Triggering Indebtedness;

WHEREAS, the Additional Guarantor, which is a Subsidiary of a Credit Party, became a Guarantor

under the Fourth Supplemental Indenture, dated as of June 9, 2025 among the Company, the Guarantors and

the Trustee, as a result of the Additional Guarantor being a guarantor in respect of Triggering Indebtedness;

WHEREAS, the Additional Guarantor is no longer a guarantor in respect of Triggering Indebtedness

and is not otherwise required to be a Guarantor pursuant to Section 1402 of the Indenture; and

WHEREAS, Section 901(5) of the Base Indenture provides that, without the consent of any Holders,

the Company, the Guarantors and the Trustee may enter into supplemental indentures to provide for the

release of any Guarantor in accordance with the Indenture.

NOW THEREFORE, in consideration of the foregoing and for other good and valuable

consideration, the receipt of which is hereby acknowledged, the Company, the Initial Guarantor, the

Additional Guarantor and the Trustee mutually covenant and agree as follows:

Section 1.01.Release of Guarantor and Termination of Guarantee. The Additional Guarantor is

hereby automatically and unconditionally released and discharged from all obligations under the Indenture

and its Guarantee.

Section 2.01.Relationship with Base Indenture. This Sixth Supplemental Indenture is executed

and shall be construed as an indenture supplemental to the Base Indenture and, as provided in the Base

Indenture, this Sixth Supplemental Indenture forms a part thereof in the manner and to the extent herein and

therein provided.

Section 2.02Trustee Makes No Representation. The recitals herein contained are made by the

Company and not by the Trustee, and the Trustee assumes no responsibility for the correctness thereof.

Trustee makes no representation as to the validity or sufficiency of this Sixth Supplemental Indenture.

Section 2.03.Successors and Assigns. All covenants and agreements in this Sixth Supplemental

Indenture by the Company and the Guarantors shall bind their respective successors and assigns, whether so

expressed or not. All agreements of the Trustee in this Sixth Supplemental Indenture shall bind its successors

and assigns, whether so expressed or not.

Section 2.04. Execution and Counterparts. This Sixth Supplemental Indenture may be executed

in any number of counterparts, each of which so executed shall be deemed to be an original, and all such

counterparts shall together constitute but one and the same instrument.

Section 2.05. Governing Law. This Sixth Supplemental Indenture shall be governed by, and

construed in accordance with, the law of the State of New York.

[Remainder of page intentionally left blank.]

[Signature Page to Sixth Supplemental Indenture]

IN WITNESS WHEREOF, the parties have caused this Fourth Supplemental Indenture to be duly

executed as of the date first written above.

[Signature Page to Sixth Supplemental Indenture]