Exhibit 10.4

October 6,2026
To:StephenMollichella
WesincerelyappreciateyourcontributionstoHarmonyBiosciences,andweconsideryour ongoingeffortstobecriticaltoourfuturesuccess.Werecognizetheadditionalworkload andresponsibilitiesthatyouhavetakenoninrecentmonthsandwewanttoacknowledge yourcontributionsthroughthisretentionbonusaward.
Thetotalretentionbonusamountis$150,000,whichwillbepaidintwoinstallmentsas follows:
●First** **installment:$100,000tobepaidonOctober15,2026
●Second** installment: **$50,000tobepaidonApril15,2027
Thisretentionbonusisconsideredsupplementalcompensationandwillbesubjecttoall applicabletaxwithholdingsanddeductions.
YouandtheCompanyacknowledgeandagreethattheRetentionBonuswillnotbeearned unlessanduntilyouarecontinuouslyandactivelyemployedwiththeCompanythroughthe one-yearanniversaryofthedatehereof.Ifyouremploymentisterminatedpriortotheone- yearanniversaryofthedatehereofbytheCompanyforCauseorbyyouortheCompanyfor anyreason,thenyouwillnotbeentitledtoretaintheRetentionBonus(orportionthereof) andyouwillbeobligatedtorepaytotheCompany,onyourterminationdate,theRetention Bonusinfullonapre-taxbasis.
Notwithstandingtheforegoing,intheeventyouremploymentisterminatedbytheCompany withoutCause(asdefinedonExhibit* *Ahereto),youwillbeentitledtoretaintheRetention Bonus, subject to your timely execution, delivery and non-revocation (if applicable) of a generalreleaseofclaimsinaformprescribedbytheCompany.
Weaskthatyoukeepthisletterandyourretentionbonusconfidential.However,nothing hereinshallprohibityoufromdisclosinganyinformationtoyourspouseoryourfinancialor taxadvisorsortotheextentthatsuchaprohibitionviolatestheNationalLaborRelationsAct orotherapplicablelaw.
Pleaseindicateyouracknowledgementof,andagreementto,thetermsandconditionsset forthinthisletter,bysigningacopyofthisletterandreturningittotheCompanyassoonas practicable.
Thank you for your continued commitment to Harmony Biosciences.
Sincerely,


/s/ Jeffrey Dayno, M.D.
By: Jeffrey Dayno, M.D.
Title: President & Chief Executive Officer
Acknowledged, Accepted and Agreed:




/s/ Stephen Mollichella10/6/2026
Stephen** MollichellaDate**
Exhibit A
Definition of “Cause”
ForpurposesofthisAgreement,“Cause”means“Cause”asdefinedinanyemploymentorconsultingagreement orsimilarservicesagreementbetweenyouandtheCompanyasineffectatthetimeor,intheabsenceofanysuch employment, consulting, or similar services agreement (or the absence of any definition of “Cause” contained therein),“Cause”meansoneormoreofthefollowing:
| (a) | yourmaterialbreachofyourobligationsunderthisAgreementoranyotheragreementorarrangement enteredintowiththeCompanyoritsaffiliates(whichremainsuncured(totheextenttheCompany reasonablydeterminescurable)foratleastten(10)businessdaysfollowingnoticeofsuchbreach); |
| (b) | yourgrossnegligenceorwillfulmisconductintheperformanceofornon-performanceofyourdutiestothe Companyoritsaffiliates; |
| (c) | yourbreachofanyoftheCompany’soritsaffiliates’writtenpoliciesorproceduresineachcaseinany respectwhichcausesorisreasonablyexpectedtocauseharmtotheCompanyoranyaffiliatethereof; |
| (d) | yourcommissionofafelonyoracrimeofmoralturpitude(ortheproceduralequivalentoftheforegoing); |
| (e) | yourcommissionofanactinvolvingdeceit,fraud,perjuryorembezzlementinvolvingtheCompanyorits affiliatesoranyclient,customer,supplierorbusinessrelationshipoftheCompanyoranyaffiliatethereof; |
| (f) | yourrepeatedlybeingundertheinfluenceofdrugsoralcohol(otherthanover-the-counterorprescription medicineorothermedicallyrelateddrugstotheextenttheyaretakeninaccordancewiththeirdirections orunderthesupervisionofaphysician)whichinhibitstheperformanceofyourdutiestotheCompanyor its affiliates, or, while under the influence of such drugs or alcohol, engaging in inappropriate conduct duringtheperformanceofyourdutiestotheCompanyoritsaffiliates;or |
| (g) | yourfailuretofollowlawfuldirectivesofyoursupervisor,which(whichfailureremainsuncured(tothe extenttheCompanyreasonablydeterminescurable)foratleastten(10)businessdaysfollowinginitial noticeofsuchfailure). |
Anyrightstocurethatareexpresslydescribedinthisdefinitionwillonlybeaffordedfortheinitialoccurrenceof anypurportedgroundsofCauseandyouwillnothaveanyright(unlessotherwiseprovidedhereinorunlessthe Companyotherwisedetermines)tocuresuchpurportedgrounds.