EX-10.410-Q·CIK 1802665·0001104659-26-122390

EX-10.4

View original filing on SEC EDGAR → ·  seen Nov 04, 2026, 08:16 EST

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FILING DETAILS

Filer
Harmony Biosciences Holdings, Inc.
Period of report
Sep 30, 2026
Filed
Nov 04, 2026
SEC file no.
001-39450
State of inc.
DE
SIC
2834
Location
PLYMOUTH MEETING, PA

Exhibit 10.4

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October 6,2026

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To:StephenMollichella

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WesincerelyappreciateyourcontributionstoHarmonyBiosciences,andweconsideryour ongoingeffortstobecriticaltoourfuturesuccess.Werecognizetheadditionalworkload andresponsibilitiesthatyouhavetakenoninrecentmonthsandwewanttoacknowledge yourcontributionsthroughthisretentionbonusaward.

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Thetotalretentionbonusamountis$150,000,whichwillbepaidintwoinstallmentsas follows:

●First** **installment:$100,000tobepaidonOctober15,2026

●Second** installment: **$50,000tobepaidonApril15,2027

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Thisretentionbonusisconsideredsupplementalcompensationandwillbesubjecttoall applicabletaxwithholdingsanddeductions.

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YouandtheCompanyacknowledgeandagreethattheRetentionBonuswillnotbeearned unlessanduntilyouarecontinuouslyandactivelyemployedwiththeCompanythroughthe one-yearanniversaryofthedatehereof.Ifyouremploymentisterminatedpriortotheone- yearanniversaryofthedatehereofbytheCompanyforCauseorbyyouortheCompanyfor anyreason,thenyouwillnotbeentitledtoretaintheRetentionBonus(orportionthereof) andyouwillbeobligatedtorepaytotheCompany,onyourterminationdate,theRetention Bonusinfullonapre-taxbasis.

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Notwithstandingtheforegoing,intheeventyouremploymentisterminatedbytheCompany withoutCause(asdefinedonExhibit* *Ahereto),youwillbeentitledtoretaintheRetention Bonus, subject to your timely execution, delivery and non-revocation (if applicable) of a generalreleaseofclaimsinaformprescribedbytheCompany.

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Weaskthatyoukeepthisletterandyourretentionbonusconfidential.However,nothing hereinshallprohibityoufromdisclosinganyinformationtoyourspouseoryourfinancialor taxadvisorsortotheextentthatsuchaprohibitionviolatestheNationalLaborRelationsAct orotherapplicablelaw.

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Pleaseindicateyouracknowledgementof,andagreementto,thetermsandconditionsset forthinthisletter,bysigningacopyofthisletterandreturningittotheCompanyassoonas practicable.

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Thank you for your continued commitment to Harmony Biosciences.

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Sincerely,

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/s/ Jeffrey Dayno, M.D.

By: Jeffrey Dayno, M.D.

Title: President & Chief Executive Officer

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Acknowledged, Accepted and Agreed:

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/s/ Stephen Mollichella10/6/2026

Stephen** MollichellaDate**

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Exhibit A

Definition of “Cause”

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ForpurposesofthisAgreement,“Cause”means“Cause”asdefinedinanyemploymentorconsultingagreement orsimilarservicesagreementbetweenyouandtheCompanyasineffectatthetimeor,intheabsenceofanysuch employment, consulting, or similar services agreement (or the absence of any definition of “Cause” contained therein),“Cause”meansoneormoreofthefollowing:

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(a) yourmaterialbreachofyourobligationsunderthisAgreementoranyotheragreementorarrangement enteredintowiththeCompanyoritsaffiliates(whichremainsuncured(totheextenttheCompany reasonablydeterminescurable)foratleastten(10)businessdaysfollowingnoticeofsuchbreach);
(b) yourgrossnegligenceorwillfulmisconductintheperformanceofornon-performanceofyourdutiestothe Companyoritsaffiliates;
(c) yourbreachofanyoftheCompany’soritsaffiliates’writtenpoliciesorproceduresineachcaseinany respectwhichcausesorisreasonablyexpectedtocauseharmtotheCompanyoranyaffiliatethereof;
(d) yourcommissionofafelonyoracrimeofmoralturpitude(ortheproceduralequivalentoftheforegoing);
(e) yourcommissionofanactinvolvingdeceit,fraud,perjuryorembezzlementinvolvingtheCompanyorits affiliatesoranyclient,customer,supplierorbusinessrelationshipoftheCompanyoranyaffiliatethereof;
(f) yourrepeatedlybeingundertheinfluenceofdrugsoralcohol(otherthanover-the-counterorprescription medicineorothermedicallyrelateddrugstotheextenttheyaretakeninaccordancewiththeirdirections orunderthesupervisionofaphysician)whichinhibitstheperformanceofyourdutiestotheCompanyor its affiliates, or, while under the influence of such drugs or alcohol, engaging in inappropriate conduct duringtheperformanceofyourdutiestotheCompanyoritsaffiliates;or
(g) yourfailuretofollowlawfuldirectivesofyoursupervisor,which(whichfailureremainsuncured(tothe extenttheCompanyreasonablydeterminescurable)foratleastten(10)businessdaysfollowinginitial noticeofsuchfailure).

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Anyrightstocurethatareexpresslydescribedinthisdefinitionwillonlybeaffordedfortheinitialoccurrenceof anypurportedgroundsofCauseandyouwillnothaveanyright(unlessotherwiseprovidedhereinorunlessthe Companyotherwisedetermines)tocuresuchpurportedgrounds.


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