Exhibit 10.2

THIRDAMENDMENTTOLEASE

THISTHIRDAMENDMENTTOLEASE(“Amendment”)ismadeandenteredintoasof April 14, 2026,byandbetweenBRANDYWINECIRA,L.P.,aPennsylvanialimitedpartnership ("Landlord"),andCABALETTABIO,INC.,aDelawarecorporation("Tenant”).

A.

Landlordand Tenantare parties to a Lease ("OriginalLease")dated as of February11, 2019, as amendedbya First Amendmentto Lease dated asof February 15, 2022, and a Second Amendment to Lease dated asof October 1,2024 (the OriginalLease assoamended is referred to herein asthe"CurrentLease"),for the Premises deemed tocontain 7,672 rentable square feet presently known as Suite 600 in the Building known asCira Centre located at 2929 Arch Street,Philadelphia, Pennsylvania.TheCurrentLease as amendedby this Amendmentis referredto hereinas the "Lease".

B.

The Term currently expires on June 30, 2026. Landlord and Tenant agree to amend the CurrentLease to extendthe Termupon the terms and conditions set forth herein.

NOW, THEREFORE, inconsideration ofthemutual covenants andagreementscontained herein, and intending tobelegallybound, LandlordandTenant hereby agreeasfollows:

1.

Incorporation of Recitals: Definitions.The recitals set forth above are hereby incorporated herein by reference as if set forth in full in the body of this Amendment. Capitalized terms used but not otherwise definedin thisAmendmenthave the respective meaningsgivento them in the CurrentLease.

2.

Term.TheTermisherebyextendedthroughNovember15,2027.

3.

Fixed Rent.Effective on July l, 2026, Tenant covenants and agrees topay to Landlord, without notice, demand, setoff, deduction,or counterclaim,Fixed Rent during theTerm asfollows, payable inadvance inthemonthlyinstallments setforthbelow andotherwiseinaccordancewith thetermsofthe Lease:

4.

Condition of Premises.Tenant acknowledges and agrees that Landlord has no obligation under the Lease to make any improvements to or perform any work in the Premises, or provide any improvementallowance,andTenantacceptsthe Premisesin their current"AS IS" condition.

5.

Brokers.Landlord and Tenant each represents and warrants to the other that such representing partyhashadnodealings, negotiations, orconsultations withrespect tothePremisesorthis transaction with any broker orfinderother than aLandlord affiliate, representing Landlord. Eachparty must indemnify, defend, and hold harmless theotherfrom and against anyand all liability, cost, and expense (including reasonable attorneys' fees and court costs), arising out of or from or related to its misrepresentation or breach of warranty under this Section. This Section will survive the expiration or earlier termination of the Term.

6.

Effect of Amendment; Ratification.Landlord and Tenant hereby acknowledge and agree that, except as provided in this Amendment, theCurrent Lease has not been modified, amended, canceled, terminated, released, superseded, or otherwise rendered of no force or effect. The Current Lease is hereby ratifiedandconfirmedbythepartieshereto,andeveryprovision,covenant,condition,obligation,right, term,andpowercontainedin andunderthe CurrentLeasecontinuesin full forceandeffect,affectedby thisAmendmentonlyto the extentofthe amendmentsandmodificationsset forth herein. Inthe eventof any conflict between theterms and conditions of this Amendmentand those of theCurrent Lease, theterms and conditions of this Amendment control. Tothe extent permitted byapplicable law, Landlord and Tenant hereby waive trial by jury in any action, proceeding, orcounterclaimbrought by either against theother on any matter arisingoutofor in anyway connectedwiththe Lease,therelationship of Landlordand Tenant, or Tenant's use or occupancy of the Building, any claim or injury or damage, or any emergency or other statutory

remedy with respect thereto. Tenant specifically acknowledges and agrees that the confession of judgmentprovisions of the Current Lease are restated in full below:

Inadditionto,andnot in lieuofanyoftheforegoingrightsgrantedtoLandlord:

(1)

WHEN THIS LEASE OR TENANT'SRIGHT OF POSSESSIONSHALL BETERMINATED BY COVENANT OR CONDITION BROKEN, OR FOR ANY OTHER REASON, EITHER DURING THE TERM OF THIS LEASE OR ANY RENEWAL OR EXTENSION THEREOF, AND ALSO WHEN AND AS SOON AS THE TERM HEREBY CREATED OR ANY EXTENSION THEREOF SHALL HAVE EXPIRED, IT SHALL BE LAWFUL FOR ANY ATTORNEY AS ATTORNEY FOR TENANT TO FILE AN AGREEMENT FOR ENTERING IN ANY COMPETENTCOURT AN ACTION TO CONFESS JUDGMENTIN EJECTMENT AGAINST TENANT AND ALL PERSONS CLAIMING UNDER TENANT, WHEREUPON, IF LANDLORD SO DESIRES, A WRIT OF EXECUTION OR OF POSSESSION MAY ISSUE FORTHWITH, WITHOUT ANY PRIOR WRIT OF PROCEEDINGS, WHATSOEVER, AND PROVIDEDIF FORANYREASONAFTERSUCHACTIONSHALLHAVEBEEN COMMENCED THE SAME SHALL BE DETERMINED AND THE POSSESSION OF THE PREMISES HEREBY DEMISED REMAIN IN OR BE RESTORED TO TENANT, LANDLORD SHALL HAVE THE RIGHT UPON ANY SUBSEQUENT DEFAULT OR DEFAULTS, OR UPON THE TERMINATIONOFTHIS LEASE AS HEREINBEFORESET FORTH, TO BRING ONE OR MORE ACTION OR ACTIONS AS HEREINBEFORE SET FORTH TO RECOVER POSSESSION OF THE SAID PREMISES.

(2)

In anyaction toconfess judgment inejectment, Landlord shallfirstcausetobefiledinsuch action an affidavit made byit or someone actingforitsettingforth thefacts necessary toauthorize theentryofjudgment,ofwhichfactssuchaffidavitshallbeconclusiveevidence,andifatruecopyof this Lease (and of the truth of the copy such affidavit shall besufficient evidence) befiled in such action,itshallnotbenecessary tofiletheoriginalasawarrantofattorney,anyruleofCourt,custom or practice tothecontrary notwithstanding.Tenantrepresents toLandlord thatithasagrossincome of at least $10,000.

TENANT WAIVER. TENANT SPECIFICALLY ACKNOWLEDGES THAT TENANT HAS VOLUNTARILY, KNOWINGLY, ANDINTELLIGENTLY WAIVED CERTAINDUEPROCESS RIGHTS TO A PREJUDGMENT HEARING BY AGREEING TO THE TERMS OF THE FOREGOING PARAGRAPHS REGARDING CONFESSION OF JUDGMENT. TENANT FURTHERSPECIFICALLYAGREESTHATINTHEEVENTOFDEFAULT,LANDLORD MAY PURSUEMULTIPLEREMEDIESINCLUDINGOBTAININGPOSSESSIONPURSUANTTOA JUDGMENT BYCONFESSION. FURTHERMORE, TENANT SPECIFICALLY WAIVES ANY CLAIM AGAINST LANDLORD AND LANDLORD'S COUNSEL FOR VIOLATION OF TENANT'SCONSTITUTIONALRIGHTSINTHEEVENTTHATJUDGMENTISCONFESSED PURSUANT TO THIS LEASE.

TENANT:CABALETTABIO,INC.

By: /s/ Steven Nichtberger

Name: Steven Nichtberger

Title: CEO

Date: 14 April 2026 | 4:40:08 PM PDT

7.

Representations.EachofLandlordandTenantrepresents andwarrants totheother that the individual executing this Amendment onsuchparty's behalf isauthorizedtodoso.

8.

Counterparts;ElectronicTransmittal.ThisAmendment maybeexecuted inanynumberof counterparts, each ofwhich when takentogether will bedeemed tobeoneand thesameinstrument. The partiesacknowledgeandagreethatnotwithstandinganylaworpresumption tothecontrary,theexchange of copies of this Amendment and signature pages by electronic transmission will constitute effective executionanddeliveryofthisAmendmentforallpurposes,andsignaturesofthepartiesheretotransmitted and/or produced electronicallywillbedeemed tobetheir original signature forallpurposes.

9.

OFAC.Eachpartyheretorepresentsandwarrantstotheotherthatsuchpartyisnotaparty with

whomtheotherisprohibitedfromdoingbusinesspursuanttotheregulationsoftheOfficeofForeign Assets Control ("OFAC")of the U.S. Department of the Treasury, including those parties named on OFAC's Specially Designated Nationals and Blocked Persons List. Each party hereto is currently in compliance with, andmust atall times during theTerm remain incompliance with, theregulations ofOFAC andanyothergovernmental requirement relatingthereto.Eachpartyheretomustdefend,indemnify, and hold harmless the other from and against any and all claims, damages, losses, risks, liabilities, and expenses (including reasonable attorneys' feesandcosts) incurred bytheothertotheextent arisingfromorrelated to any breach of the foregoing certifications. The foregoing indemnity obligations will survive the expiration or earlier termination of the Lease.

[SIGNATURESONFOLLOWINGPAGE]

INWITNESSWHEREOF,LandlordandTenanthave dulyexecutedthisAmendmentasof the date first-above written.

LANDLORD:

BRANDYWINE CIRA, L.P.

By: Brandywine Cira, L.L.C., its general partner

By: /s/ Stephen Rush

Name: Stephen Rush

Title: Vice President

Date: 4/14/2026

TENANT:

CABALETTA BIO, INC.

By: /s/ Steven Nichtberger

Name: Steven Nichtberger

Title: CEO

Date: 14 April 2026 | 4:40:08 PM PDT